The Synergistic Antitumor Activity of Colchicine and Chloroquine

Abstract

The investigation of the synergistic antitumor activity between chloroquine and colchicine has been conducted in the context of treating breast cancer. Breast cancer is the most prevalent malignancy among women and a global health concern. Developing resistance to drugs presents an obstacle to the efficacy of chemotherapy. The objective of this research endeavor was to investigate the potential of colchicine and chloroquine in combination as a supplementary or alternative therapy to traditional chemotherapy. The study's objective was to evaluate the cytotoxic, anti-proliferative, and apoptosis-inducing effects on breast cancer cell lines. The results of the study indicated that colchicine and chloroquine, when combined, exerted a noteworthy synergistic impact on breast cancer cells. Enhanced cytotoxicity, inhibition of proliferation, induction of morphological changes, and apoptosis were all outcomes of the combination therapy. The synergistic effect between chloroquine and colchicine was confirmed by isobologram analysis, which revealed a high degree of synergy. The results of this study underscore the potential efficacy of combining colchicine and chloroquine as a therapeutic strategy for breast cancer. Combination therapy provides the benefit of increased effectiveness with the potential to decrease the dosage of traditional treatments, mitigate adverse effects, and surmount resistance to chemotherapy. Additional research and clinical trials are necessary to validate and apply these results in the field.