Formulation And Development Of Transdermal Patches Of Amoxicillin And Comparative Effect Of Natural Permeation Enhancers On Ex Vivo Release

Abstract

The motive for this research work was to create and assess matrix type transdermal patches containing Amoxicillin with various polymers and to investigate the effect of extracts of Cumin seeds extracts on the bioavailability of Amoxicillin. The physicochemical similarity of the medication and the polymers were studied by Fourier Transform Infrared (FTIR) Spectroscopy. The outcomes recommended no physicochemical incongruence between the medication and the polymers. The formulated transdermal patches were assessed for weight variation, thickness, folding endurance, moisture loss, moisture absorption, ex-vivo drug release, ex-vivo drug absorption. The diffusion examines were performed by utilizing the Franz Diffusion cell and Everted gut Sac method. The best formulation F25 showed Thickness 0.112±0.004mm, Weight uniformity 0.139±0.004gm, % Moisture uptake 8.154±2.324, % Moisture content 6.121±0.324, % Drug content 82.44±0.231, Folding endurance30±4.11. Formulation F25 exhibits the highest % cumulative drug release 80.34±0.34% in 8hrs and highest %Drug absorbed 4.454±0.21 in 120 min.