Formulation And Evaluation Studies Of Anti-Hiv Topical Gels

Abstract

The present work describes that Acyclovir drug is selected for the study because it has good percutaneous absorption and appears to be more active as antiviral activity and is well tolerated. The polymers namely Carbopol-934, Carbopol-940, Hydroxypropyl methyl cellulose and Sodium carboxy methyl cellulose were used for formulation of gels and studied for their drug release from the gel formulations. It is evidence from the IR spectrum that all the polymers used in the gel formulations were compatible with the drug Acyclovir. In vitro release studies of the formulations were carried out across the cellophane membrane using a diffusion cell. The release was highest for the formulation A₂ (1%Carbopol-934) and on the addition of DMSO as a permeation enhancer the drug release was improved.

The formulation B₂, C₃ and D₂ also have significant percentage release and on addition of DMSO as a permeation enhancer the drug release from gel formulation was improved. Hence based on the above results, out of 13 formulations A₂ was chosen as the best formulation.