Effects Of Alcoholic Leaf Extract Of Hunteria Umbellata On Various Parameters In Wistar Female Rats Exposed To Trichloroethylene (TCE)

Abstract

This investigation examined the effects of alcoholic Hunteria umbellata leaf extract on several parameters in Wistar female Albino rats exposed to trichloroethylene (TCE). The study assessed body weight changes, antioxidant activity, lipid profile, hematological parameters, and kidney biomarkers. Regarding body weight, the treatment groups showed a significant increase compared to the negative control, which exhibited weight loss. The administration of Hunteria umbellata extract resulted in weight gain in a dose-dependent manner. Antioxidant activity analysis demonstrated that TCE exposure led to a decrease in catalase (CAT) and superoxide dismutase (SOD) levels while malondialdehyde (MDA) levels increased. However, treatment with Hunteria umbellata extract showed a significant improvement in antioxidant activity, with increased levels of CAT and SOD and decreased MDA levels.

The extract had favorable effects on the lipid profile, raising levels of high-density lipoprotein (HDL) and lowering those of low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), cholesterol, and triglyceride (TAG). Hematological parameters analysis showed that the extract administration had positive effects on red blood cell (RBC) count, packed cell volume (PCV), hemoglobin (Hb), white blood cell (WBC) count, and platelet levels. It also influenced the levels of neutrophils, lymphocytes, monocytes, eosinophils, and basophils. Furthermore, the study assessed kidney biomarkers, including sodium (Na+), chloride (Cl-), potassium (K+), bicarbonate (HCO3-), urea, and creatinine levels. Treatment with Hunteria umbellata extracts improved biomarker levels, indicating potential kidney protection against TCE-induced damage. In conclusion, the alcoholic leaf extract of Hunteria umbellata exhibited beneficial effects on body weight, antioxidant activity, lipid profile, hematological parameters, and kidney biomarkers in TCE-induced Wistar female Albino rats. These results raise the possibility that Hunteria umbellata extract has potential protective effects against TCE-induced toxicity. More study is required to clarify the underlying mechanisms and evaluate their safety and effectiveness in human beings.