Impact Of Total Parenteral Nutrition On Liver Function In Long-Term Patients

Abstract

In the second half of the last century, total parenteral nutrition (TPN) achieved a major change in the management of potentially reversible, life-threatening malnutrition. It allowed patients either to regain adequate feeding for short or eventually longer recovery from multiple nonfunctioning organ systems or throughout long-lasting disease or other malabsorption, with the expectation that disorderly function would give way to a new balance of body functions and morphology without any need for organ replacement or to be held in good nutrition and metabolism status when they were in danger of long-lasting fasting during either acute illness without need for hospitalization or towards chronicity of otherwise highly treatable morbidities after recovery from life-threatening malnourishment. Therefore, this was the decade indexing the ethics of involuntary research trials, incidents secondary to massive clinical use of illicit drugs, and transplant immunosuppression without rigorous careful dosing. (Wanchoo, 2022)